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ARIMIDEX (anastrozole) promotes the decline in the level of estrogen in postmenopausal age women to slow the development of certain cancerous tumours. It acts by inhibiting the aromatase enzyme, and therefore the production of estrogen.

Dosage and administration
Follow all the instructions of your physician for the program of treatment and dosage. Do not take this medication more than the prescribed dose. Take the once a day.

Precautions
Tell your doctor if you are pregnant or breastfeeding, if you have liver disease acute, a history of access of blood clotting, heart disease, circulation problems, or if you have not yet reached menopause. If you have such problems, you need probably your dose correction. Your treatment in the Arimidex may last up to five years. This medication can decrease your concentration and mental abilities or reaction: be particularly cautious if you drive or work on machines.

Contraindications
ARIMIDEX is discouraged among women of premenopausal age, women pregnant or lactating, suffering acute kidney problems, liver diseases mild and severe hypersensitivity to Arimidex or other components of the drug. Estrogen-containing products are to be avoided during treatment, that they neutralize its pharmacological effect of Arimidex.

Possible side effects
The most common side effects include aggravation of allergies (eruptions, skin redness, swelling of the face and breathing disorders) accompanied by headaches sudden, mental disorders, vision problems, oratory, or loss of balance, numbness, or sudden weakness, especially on one side of the body, fracture of bone, swelling of glands, swelling hands or feet. More or less rare symptoms such as severe unpleasant reactions as sharp sensations of heat, sore throat, weakness, back pain, pain in the bones, nausea may occur.

Drug interaction
Tell your doctor if you are taking tamoxifen or estrogen. Tell your doctor of all prescription and non-prescrits prescription drugs, products of herbs, vitamins and additives that you used.

Dose failure
If you omitted a dose, take it as soon as you're reminded you. If the time of your next dose taken is near, let go simply and return to your regular program. NE never double the dose of this drug.

Overdose
There is no information on the dosage of Arimidex. If you think you have taken too much of this medicine, contact your doctor immediately.

Conservation
Keep at a temperature of between 20-25 C (68-77 F) House. Place the drug moisture, heat and light from the Sun. It is not recommended to keep in room bathroom and accessible to children.

Disclaimer (disclaimer notice)
We provide information only General characters on drugs which include not all areas, the possible polyvalences of the drug, or precautions. Information on the site can be used for a personal treatment and a personal diagnosis. Any specific statement for a particular patient should be consulted with your health care advisor or your physician in charge of the case. We reject any reference to the undeniable character of the information and errors they might contain. Us ne are not responsible for any damage direct or indirect, special or other damages from any use of the information on this site and also for the consequences of the self-treatment.

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Anastrozole marketed under the trade name Arimidex, is a drug used to treat breast cancer after surgery and for metastases in both pre and post-menopausal women ...
While officially indicated for women, this drug has proven effective in the off-label use of reducing estrogens in men. ...
Some athletes and body builders will also use anastrozole as a part of their steroid cycle to reduce and prevent symptoms of excess estrogens; in particular, gynecomastia and water retention.
Wikipedia

The drug is a well-known and widespread, even in the sports sector. You use especially in association with anabolic steroids, to attenuate their effects and maximize the earning strength and hypertrophy.

Excess testosterone, resulting from exogenous hormone or its derivatives, is partly neutralized by the enzyme aromatase, which concentrated mainly at the level-of adipose tissue-it transforms a certain quota to estrogen.

The Arimidex, blocking the aromatase, prevents the long list of side effects associated with overproduction of estrogen: retention, accumulation of fat, Gynecomastia and negative feed-back on the secretion of LH from the anterior pituitary.

The Arimidex is very useful in sport where weight gain (retention more fat) is a limiting factor for the sporting performance or aesthetics (see bodybuilding). If the only purpose is to increase strength and muscle mass, anastrozole may be required in the drawer, since estrogen contribute significantly important to the growth of skeletal muscles. Not surprisingly, the anabolic steroids aromatizzabili (convertible to estrogen) are much higher than those of the anabolic activity with low estrogen.

The is typically used in combination with anabolic steroids from powerful androgenic activity, such as Dianabol or testosterone, along with an inhibitor of the enzyme 5-alpha reductase (Finasteride or Dutasteride), useful to limit the adverse effects associated with overproduction of DHT (hair loss, acne, oily skin, prostatic hypertrophy, and the like).

In sports, the Arimidex is taken at doses similar to those proposed in the fight against breast cancer: a capsule from 1 mg per day, sometimes even half, is usually sufficient.

There are, of course, the side effects. In addition to striking drop in volume of loan portfolio (Arimidex is a very expensive drug), the association with anabolic steroids boosts the reduction of plasma levels of good cholesterol HDL induced by the latter. Under this aspect, other medications anti-estrogenic, such as Clomid and Nolvadex ® ® are preferred, as exempt from similar effects (Nolvadex, interacting with estrogen receptors in the liver, promotes an increase of HDL).

Arimidex may not work as well if you take it together with tamoxifen or an estrogen medication.
You should not use Arimidex if you are allergic to anastrozole, or if you are pregnant or breast-feeding.
Arimidex is usually taken once per day. Store this medicine at room temperature away from moisture and heat.
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention if you think you have used too much of this medicine. The symptoms of an Arimidex overdose are not known.

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Arimidex is a powerful inhibitor NSAID, and highly selective aromatase. In postmenopausal women, oestradiol is produced mainly in peripheral tissues as a result of the conversion, by the enzyme aromatase into estrone, androstenedione. The estrone is then subsequently converted to estradiol. It has been shown that the reduction of plasma levels of estradiol determines a beneficial effect in women suffering from breast cancer. In postmenopausal women on Arimidex 1 mg daily dose led to a suppression of estradiol levels in excess of 80%. Such concentrations have been measured with a highly sensitive test.

Arimidex has no androgenic activity or progestin, estrogen.

Daily doses of Arimidex to 1 mg have not shown any effect on the secretion of cortisol or aldosterone test measured before or after stimulation with ACTH standards. Therefore do not require additional administration of corticosteroids.

Adjuvant treatment of primary stages of breast cancer

In a large phase III study conducted in 9366 postmenopausal women with operable breast cancer treated for 5 years, Arimidex showed statistically superior to tamoxifen in relation to disease-free survival. The benefit observed in disease-free survival was higher in patients with hormone receptor positive, prospectively defined. Arimidex is statistically superior to tamoxifen in regards to re-offending. The difference was greater than that observed for disease-free survival for the total population and for population with hormone receptor positive. Arimidex is statistically superior to tamoxifen in time to recurrence. The incidence of carcinoma of the contralateral breast was statistically reduced Arimidex versus tamoxifen. After five years of therapy anastrozole is at least as effective as tamoxifen in terms of overall survival. However, due to low rates of deaths, is required a further follow-up to determine more precisely the long-term survival of anastrozole versus tamoxifen. With a median follow-up of 68 months patients in ATAC not were followed for long enough after 5 years of treatment to allow a comparison of the long-term effects of treatment with Arimidex versus tamoxifen.